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molecule compound library  (TargetMol)
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TargetMol molecule compound library
Screening <t>of</t> <t>small-molecule</t> compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h
Molecule Compound Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small-molecule+screening/pmc11787111-128-1-7?v=TargetMol
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molecule compound library - by Bioz Stars, 2026-07
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2020 novartis small molecule screening deck  (Novartis)
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Novartis 2020 novartis small molecule screening deck
Screening <t>of</t> <t>small-molecule</t> compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h
2020 Novartis Small Molecule Screening Deck, supplied by Novartis, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small-molecule+screening/pm42150410-202-21-22?v=Novartis
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2020 novartis small molecule screening deck - by Bioz Stars, 2026-07
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small molecule screening library  (Chembridge)
86
Chembridge small molecule screening library
Screening <t>of</t> <t>small-molecule</t> compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h
Small Molecule Screening Library, supplied by Chembridge, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small-molecule+screening/us12565673-81-3-14?v=Chembridge
Average 86 stars, based on 1 article reviews
small molecule screening library - by Bioz Stars, 2026-07
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small molecule dpp4 screening model  (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc small molecule dpp4 screening model
Screening <t>of</t> <t>small-molecule</t> compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h
Small Molecule Dpp4 Screening Model, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small-molecule+screening/pm40597132-271-0-25?v=Cell+Signaling+Technology+Inc
Average 90 stars, based on 1 article reviews
small molecule dpp4 screening model - by Bioz Stars, 2026-07
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high content screening of small molecules  (Broad Institute Inc)
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Broad Institute Inc high content screening of small molecules
Screening <t>of</t> <t>small-molecule</t> compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h
High Content Screening Of Small Molecules, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small-molecule+screening/us12325866-1081-17-23?v=Broad+Institute+Inc
Average 90 stars, based on 1 article reviews
high content screening of small molecules - by Bioz Stars, 2026-07
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small molecule screening and initial compound retesting  (WuXi AppTec)
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WuXi AppTec small molecule screening and initial compound retesting
Screening <t>of</t> <t>small-molecule</t> compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h
Small Molecule Screening And Initial Compound Retesting, supplied by WuXi AppTec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small-molecule+screening/pm40366200-605-9-15?v=WuXi+AppTec
Average 90 stars, based on 1 article reviews
small molecule screening and initial compound retesting - by Bioz Stars, 2026-07
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cell-based small-molecule screening  (Proteostasis Therapeutics)
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Proteostasis Therapeutics cell-based small-molecule screening
Screening <t>of</t> <t>small-molecule</t> compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h
Cell Based Small Molecule Screening, supplied by Proteostasis Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small-molecule+screening/pm40305178-12-4-9?v=Proteostasis+Therapeutics
Average 90 stars, based on 1 article reviews
cell-based small-molecule screening - by Bioz Stars, 2026-07
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small molecule screening data  (Mendeley Ltd)
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Mendeley Ltd small molecule screening data
Screening <t>of</t> <t>small-molecule</t> compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h
Small Molecule Screening Data, supplied by Mendeley Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small-molecule+screening/pmc10925838-1513-0-11?v=Mendeley+Ltd
Average 86 stars, based on 1 article reviews
small molecule screening data - by Bioz Stars, 2026-07
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cell titer-glo data from oci-ly1 cayman epigenetic small molecule screen  (Cayman Chemical)
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Cayman Chemical cell titer-glo data from oci-ly1 cayman epigenetic small molecule screen
Screening <t>of</t> <t>small-molecule</t> compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h
Cell Titer Glo Data From Oci Ly1 Cayman Epigenetic Small Molecule Screen, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small-molecule+screening/bio_rxiv__2025__01__31__635709-187-2-7?v=Cayman+Chemical
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cell titer-glo data from oci-ly1 cayman epigenetic small molecule screen - by Bioz Stars, 2026-07
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Screening of small-molecule compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h

Journal: Cancer Immunology, Immunotherapy : CII

Article Title: ANKRD22 participates in the proinflammatory activities of macrophages in the colon cancer tumor microenvironment

doi: 10.1007/s00262-024-03930-z

Figure Lengend Snippet: Screening of small-molecule compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h

Article Snippet: The small-molecule compound library used was the Topscience Database, which comprises 7,272,880 compounds.

Techniques: Expressing, Derivative Assay